結論

利用(yong)界面(mian)(mian)張力、核磁共(gong)振和熒光等方(fang)法研究(jiu)了Mega-10和DPS在(zai)(zai)(zai)水溶(rong)液和α-CD水溶(rong)液中(zhong)的(de)(de)(de)(de)混(hun)合(he)(he)(he)(he)界面(mian)(mian)單分子膜和混(hun)合(he)(he)(he)(he)膠(jiao)束(shu)的(de)(de)(de)(de)物理(li)(li)化學性(xing)(xing)質。兩(liang)種(zhong)表(biao)面(mian)(mian)活性(xing)(xing)劑(ji)與α-CD形成(cheng)(cheng)包(bao)合(he)(he)(he)(he)物，導致兩(liang)種(zhong)表(biao)面(mian)(mian)活性(xing)(xing)劑(ji)的(de)(de)(de)(de)表(biao)面(mian)(mian)過量減少，表(biao)觀(guan)cmc增加(jia)(jia)。Ka值表(biao)明(ming)，DPS與α-CD形成(cheng)(cheng)的(de)(de)(de)(de)包(bao)合(he)(he)(he)(he)物比(bi)Mega-10強。在(zai)(zai)(zai)這兩(liang)種(zhong)情況下(xia)，復合(he)(he)(he)(he)物的(de)(de)(de)(de)形成(cheng)(cheng)是由于(yu)(yu)表(biao)面(mian)(mian)活性(xing)(xing)劑(ji)分子的(de)(de)(de)(de)脂肪族(zu)鏈包(bao)含在(zai)(zai)(zai)α-CD的(de)(de)(de)(de)疏水空(kong)腔(qiang)中(zhong)。實(shi)驗(yan)測定的(de)(de)(de)(de)混(hun)合(he)(he)(he)(he)cmc在(zai)(zai)(zai)α-CD存在(zai)(zai)(zai)下(xia)接近理(li)(li)想(xiang)cmc*，表(biao)明(ming)混(hun)合(he)(he)(he)(he)膠(jiao)束(shu)的(de)(de)(de)(de)形成(cheng)(cheng)在(zai)(zai)(zai)本質上接近理(li)(li)想(xiang)。在(zai)(zai)(zai)不同濃度的(de)(de)(de)(de)α-CD存在(zai)(zai)(zai)下(xia)，相互作用(yong)參數bmic 12的(de)(de)(de)(de)值接近于(yu)(yu)零，這表(biao)明(ming)在(zai)(zai)(zai)混(hun)合(he)(he)(he)(he)膠(jiao)束(shu)形成(cheng)(cheng)過程(cheng)中(zhong)不存在(zai)(zai)(zai)協(xie)同或拮抗行為，因此該(gai)過程(cheng)接近理(li)(li)想(xiang)。熒光各向異性(xing)(xing)數據(ju)表(biao)明(ming)，在(zai)(zai)(zai)我們的(de)(de)(de)(de)實(shi)驗(yan)條件下(xia)，探針(zhen)RB不與表(biao)面(mian)(mian)活性(xing)(xing)劑(ji)單體結合(he)(he)(he)(he)。各向異性(xing)(xing)值隨(sui)著(zhu)α-CD的(de)(de)(de)(de)增加(jia)(jia)而減小，表(biao)明(ming)隨(sui)著(zhu)DPS摩爾分數的(de)(de)(de)(de)增加(jia)(jia)，膠(jiao)束(shu)結構的(de)(de)(de)(de)剛性(xing)(xing)和有序性(xing)(xing)降(jiang)低(di)。在(zai)(zai)(zai)不同的(de)(de)(de)(de)α-CD濃度下(xia)，由于(yu)(yu)膠(jiao)束(shu)濃度的(de)(de)(de)(de)降(jiang)低(di)，Mega-10的(de)(de)(de)(de)剛性(xing)(xing)結構形成(cheng)(cheng)更加(jia)(jia)明(ming)顯(xian)。

致謝

P.S.感(gan)(gan)謝日(ri)(ri)本科學促進會（JSPS）獲得博士后(hou)獎。我(wo)(wo)們感(gan)(gan)謝日(ri)(ri)本大(da)阪城市大(da)學生(sheng)物應用(yong)化(hua)學系T.長崎博士的熒光各向異性測量。R.W.承認OCU獎學金。我(wo)(wo)們要感(gan)(gan)謝Kinoshita教授使用(yong)核(he)磁共振(zhen)設(she)備。D.E.O得到丹麥研究基金會（InS紡）和維蘭姆(mu)-坎(kan)恩-拉斯姆(mu)森(sen)基金會（BioNET）的支持(chi)。

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